Archives

2024

Vol 2, No 1 (2024): Role of Physicochemical Properties in Drug Design and Development

Author: Aarti Rao

Abstract: This paper explores the crucial role of physicochemical properties in drug design and development. It examines how these properties influence various stages of drug discovery, from molecular design to formulation and pharmacokinetics. Key methods for assessing and optimizing these properties are discussed, highlighting their impact on drug efficacy and safety.

Keywords: Physicochemical properties, Drug design, Pharmacokinetics, Pharmacodynamics, Formulation, Drug delivery, Regulatory considerations, Computational modeling, Solubility, Permeability, Stability

Vol 2, No 1 (2024): Advances in Nanoparticle-Based Drug Delivery Systems: Design, Characterization, and Applications

Authors: Rahul Jain, Anjali Mehta

Abstract:Nanoparticle-based drug delivery systems have emerged as versatile platforms in modern pharmacotherapy, offering unprecedented control over drug release kinetics, targeting specificity, and biocompatibility. This paper reviews recent advances in the design, characterization, and applications of nanoparticle-based drug delivery systems.

The introduction highlights the persistent challenges in conventional drug delivery methods, such as poor bioavailability, off-target effects, and rapid clearance from circulation, which nanoparticles aim to address. Key design strategies are explored, including the use of lipid-based, polymeric, and inorganic nanoparticles, each tailored to optimize drug encapsulation efficiency and therapeutic efficacy.

Characterization techniques, essential for understanding nanoparticle physicochemical properties, are detailed. These include dynamic light scattering and transmission electron microscopy for size and morphology assessment, as well as Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy for compositional analysis and drug loading validation.

Keywords: Nanoparticle-based drug delivery, Lipid nanoparticles, Polymeric nanoparticles, Inorganic nanoparticles, Targeted drug delivery, Characterization techniques, Biocompatibility, Theranostics

Vol 2, No 1 (2024): Evaluating the Cost-Effectiveness of Novel Drug Formulations in Modern Healthcare

Authors: Varun Kumar, Kavita Singh

Abstract: The rapid development of novel drug formulations has revolutionized modern healthcare, offering enhanced therapeutic benefits and improved patient outcomes. However, evaluating the cost-effectiveness of these innovations is critical to ensure sustainable healthcare systems. This paper aims to analyze the economic impact of novel drug formulations, comparing them to traditional therapies. Through a comprehensive review of current literature and case studies, we will present key findings on cost-effectiveness, supported by tables and figures illustrating cost-benefit analyses, patient outcomes, and healthcare system impacts.

Keywords: Cost-effectiveness, Novel drug formulations, Modern healthcare, Biologics, Biosimilars, Targeted therapies, Incremental cost-effectiveness ratio (ICER), Quality-adjusted life year (QALY), Healthcare economics, Patient outcomes.

 

Vol 2, No 1 (2024): Strategies to Prolong Drug Release and Maintain Therapeutic Levels over Time

Author: Neha Patel

Abstract: The optimization of drug delivery systems to prolong drug release and maintain therapeutic levels in the bloodstream is a critical aspect of pharmacotherapy. This paper reviews various strategies employed to enhance drug stability, control release kinetics, and achieve sustained therapeutic efficacy. Techniques such as the development of novel polymeric matrices, incorporation of micro- and nanotechnologies, use of lipid-based formulations, and application of smart drug delivery systems are explored. Additionally, the role of bioengineering approaches, such as hydrogels and micelles, as well as the use of controlled-release technologies like osmotic pumps and reservoir systems, are discussed. The review highlights the advantages and challenges associated with these strategies, providing insights into their potential applications in clinical settings to improve patient outcomes and reduce side effects.

Keywords: Drug delivery, sustained release, polymeric matrices, nanotechnology, lipid-based formulations, controlled-release systems, therapeutic efficacy, hydrogels, osmotic pumps.

Vol 2, No 1 (2024): Bioconjugation and Targeted Drug Delivery: An Overview

Authors: Payal Sharma, Hitesh Singh

Abstract: Bioconjugation and targeted drug delivery are pivotal fields in modern medicine, promising increased efficacy and reduced side effects in therapeutic interventions. This paper delves into the fundamental principles of bioconjugation, explores various techniques and applications, and emphasizes the significant role of targeted drug delivery in enhancing therapeutic outcomes. The integration of these two fields represents a leap forward in personalized medicine, providing the framework for precision therapies that align with the unique biological characteristics of individual patients.

Keywords: Bioconjugation, targeted drug delivery, antibody-drug conjugates, nanoparticles, precision medicine, therapeutic agents, biomaterials, drug delivery systems, personalized medicine, therapeutic efficacy.

 


2023

Vol 1, No 2 (2023): Critical Examination of High-Performance Liquid Chromatography Methodology: Development and Validation

Authors:-Deepti Gusain, Kavya Thakur

Abstract:-High-Performance Liquid Chromatography (HPLC) stands as the predominant separation technique for the detection, separation, and quantification of drugs. The versatility of HPLC makes it especially effective for analyzing multi-component dosage forms, owing to its advantages such as speed, specificity, accuracy, precision, and ease of automation. The application of HPLC extends to pivotal roles in the discovery, development, and manufacturing of pharmaceutical drugs, as well as in various studies related to both human and animal subjects. This review provides insights into the different stages involved in the development and validation of HPLC methods. The validation process, aligned with ICH guidelines, encompasses key performance characteristics including accuracy, precision, specificity, linearity, range, limit of detection, limit of quantification, robustness, and system suitability testing.

Keywords:-Pharmaceutical drugs, HPLC (high pressure liquid chromatography) method development, validation.

Vol 1, No 2 (2023): Revolutionizing Pharmaceutical Efficacy: Nano technological Approaches to Enhance Drug Solubility and Bioavailability

Authors:-Deeksha Dua, Nisha Bisht

Abstract:-The pharmaceutical industry continually strives to improve drug efficacy by overcoming challenges related to drug solubility and bioavailability. This paper explores the revolutionary potential of Nano technological approaches in addressing these challenges. The research problem revolves around the limited bioavailability of poorly water-soluble drugs, which hampers their therapeutic effectiveness. This paper aims to investigate how nanotechnology can enhance drug solubility and bioavailability, ultimately transforming pharmaceuticals. The methodology involves a comprehensive literature review, examining various Nano technological approaches such as nanoparticles, liposomes, and micelles as advanced drug delivery systems. Key findings highlight the promising role of nanotechnology in enhancing solubility and bioavailability, enabling more effective drug delivery. The implications of this research are profound, potentially revolutionizing pharmaceutical development and patient treatment.

Keywords:-Nanotechnology, Drug solubility, Bioavailability, Drug delivery systems, Nanoparticles, Liposomes, Pharmaceutical efficacy

Vol 1, No 2 (2023): A Study on UV Spectrophotometric Quantification of Famciclovir in Drug Formulations

Authors:-Deepika Soni, Kunal Verma

Abstract:-A straightforward, swift, precise, and sensitive UV-spectrophotometric method has been developed for the analysis of Famciclovir in pharmaceutical formulations. The methodology utilizes 0.1 N HCl as the solvent and measures absorbance at 312 nm. The linearity of the substance within the concentration range of 2-12 g/ml is evident with a high correlation coefficient of 0.9978. The recovery rate of the drug falls within the range of 98.62% to 100.5%. The validation of the method complies with ICH criteria. This cost-effective and sensitive approach is applicable for the estimation of Famciclovir in both bulk and tablet dosage forms.

Keywords:-Famciclovir; 0.1 N HCl; UV-spectrophotometric method; ICH guidelines


Vol 1, No 2 (2023): Revolutionizing Overdose Treatment: Innovations in Antidote Development and Drug Overdose Management Strategies

Authors:-Santosh Narwane, Jayendra Saini, Aarti Sharma

Abstract:-The escalating incidence of drug overdoses globally necessitates urgent advancements in antidote development and overdose management strategies. This paper provides an in-depth exploration of recent innovations in this field, focusing on pharmacological and therapeutic approaches to mitigate the consequences of drug toxicity. We employed a comprehensive methodology, including an extensive literature review and case study analysis, to glean insights from recent developments and historical data. This paper highlights significant innovations such as novel antidote formulations, improved administration methods, and integrated management protocols that have shown promise in enhancing the efficacy of overdose treatment. A notable finding is the emergence of targeted antidotes that address specific overdose complexities, reflecting a shift towards personalized medical interventions in emergency medicine. These advancements not only offer improved survival rates and outcomes for overdose patients but also pave the way for more effective, timely, and patient-centric approaches in emergency medical care. The implications of these findings extend beyond immediate medical responses, suggesting a framework for future research and policy development in drug safety and public health.

Keywords:-Antidote Development, Drug Overdose, Overdose Management, Pharmacological Innovations, Emergency Medicine.

 

Vol 1, No 2 (2023): Drug Repurposing Exploring New Therapeutic Avenues for Existing Compounds

Authors:-Shalini Tiwari, Mansi Sirohi

Abstract:-Drug repurposing, also known as drug repositioning or reprofiling, has emerged as a promising strategy in drug discovery and development. This approach involves identifying new therapeutic applications for existing drugs, compounds, or agents that have already undergone clinical testing for other indications. Drug repurposing offers several advantages, including reduced development costs, shortened timelines, and the potential to address unmet medical needs. This paper provides an overview of the concept of drug repurposing, explores various methods employed in identifying repurposable candidates, and highlights successful examples of drugs that have been repurposed for different medical conditions. Additionally, we discuss the challenges and opportunities associated with drug repurposing, emphasizing its potential to revolutionize the field of medicine.

Keywords:-Drug Repurposing, Drug Discovery, Therapeutic Avenues, Computational Approaches, High-Throughput Screening, Systematic Literature Reviews, Intellectual Property, Regulatory Challenges, Combination Therapies, Advanced Technologies, Personalized Medicine, Patient-Centric Approaches.

Vol 1, No 1 (2023): Niosomes: A Versatile Drug Delivery System for Enhanced Therapeutic Efficacy

Authors:  Deepak Gowda

Abstract: Drug delivery systems play a crucial role in enhancing the therapeutic efficacy and safety of pharmaceutical agents. Among the various drug delivery systems, niosomes have emerged as a promising platform due to their unique structural and functional properties. Niosomes are non-ionic surfactant-based vesicles that offer numerous advantages over conventional drug delivery systems. This paper aims to provide an overview of niosomes as a novel drug delivery system, including their composition, preparation methods, characterization techniques, and applications. The potential of niosomes in improving drug delivery and addressing challenges associated with traditional delivery systems makes them a promising tool for the pharmaceutical industry.

Keywords: Niosomes, drug delivery system, non-ionic surfactants, vesicles, composition, preparation methods, characterization, advantages, applications, challenges, future perspectives.

Vol 1, No 1 (2023): The Role of Nanotechnology in Drug Delivery Systems

Authors : Ayush Dutta, Vishal Singh, Satish Kalluri

Abstract: Nanotechnology has revolutionized various fields, including medicine and pharmaceuticals. In recent years, it has emerged as a promising approach for enhancing drug delivery systems. Nanoparticles and nanocarriers offer several advantages over conventional drug delivery methods, including improved solubility, enhanced bioavailability, targeted drug delivery, and controlled release. This paper explores the role of nanotechnology in drug delivery systems and highlights its potential to revolutionize the field of medicine.

Keywords: Nanotechnology, drug delivery, nanoparticles, nanocarriers, controlled release systems, targeted drug delivery, biocompatibility, passive targeting, active targeting, personalized medicine.

Vol 1, No 1 (2023): Emerging Trends in Drug Formulation and Development: Harnessing Artificial Intelligence and Machine Learning

Authors:  Dr. Digvijay Pandey, Amit Kumar

Abstract: The field of drug formulation and development has witnessed significant advancements over the past few decades, driven by innovative technologies and methodologies. In recent years, artificial intelligence (AI) and machine learning (ML) have emerged as powerful tools with the potential to revolutionize the drug discovery process. This paper aims to explore the emerging trends in drug formulation and development, focusing on the applications of AI and ML in various stages of the drug development pipeline. We discuss how these technologies are being utilized to expedite the discovery of new drug candidates, optimize drug formulations, and personalize treatment regimens. Additionally, we explore the challenges and future prospects of integrating AI and ML into the pharmaceutical industry.

Keywords: Artificial Intelligence, Machine Learning, Drug Formulation, Drug Development, Personalized Medicine, Treatment Optimization, Predictive Modeling, Optimization, Stability Prediction, Quality by Design.

Vol 1, No 1 (2023): Application of Machine Learning Algorithms in Drug Discovery

Authors:  Devraju Reddy, Paras Agarwal, Harish Punj

Abstract: The discovery and development of new drugs is a complex and time-consuming process. Traditional methods for drug discovery rely on experimental trial and error, which is costly and inefficient. In recent years, machine learning algorithms have emerged as powerful tools for accelerating the drug discovery process. This paper aims to explore the various applications of machine learning algorithms in drug discovery and highlight their potential to revolutionize the field. Furthermore, we present examples of successful applications and discuss challenges and future prospects.

Keywords: Machine learning, Drug discovery, Artificial intelligence, Target identification, Virtual screening, Lead generation, Structure-based drug design, Toxicity prediction, Pharmacokinetic, ADME properties

Vol 1, No 1 (2023): Advancements in Nanotechnology for Drug Formulation: Enhancing Bioavailability and Targeted Delivery

Authors:  Aditya Khatri, Prashant Verma

Abstract: Nanotechnology has revolutionized the field of drug formulation, offering unprecedented opportunities to enhance drug delivery systems. This paper provides an overview of the advancements in nanotechnology for drug formulation, with a specific focus on improving bioavailability and enabling targeted delivery. Various nanoscale systems, including liposomes, polymeric nanoparticles, and dendrimers, are discussed, highlighting their potential applications in overcoming the limitations of conventional drug delivery methods. The paper also explores the challenges and future prospects of nanotechnology-based drug formulation, emphasizing the need for continued research and development to harness the full potential of nanotechnology in the healthcare industry.

Keywords: Nanotechnology, drug formulation, bioavailability, targeted delivery, nanoscale drug delivery systems, poor solubility, stability, biological barriers, passive targeting, active targeting, stimuli-responsive, imaging-guided, personalized medicine, combination therapies, intelligent systems.


Vol 1, No 1 (2023): Anjjan - Kriyakalpa for Disorders of Netraroga WSR to Sushruta Samhita

Author: Prof. Vd. Upendra U. Zala

Abstract: Rasashastra is a most important and popular branch of Ayurveda. The initial concept of Rasashastra is Dhatuvad & Dehavad. That why transform lower metals into Nobel metals, and after worlds to make the body tissues strong and to maintain their healthy state with a view to remove poverty from the world first and then to remove senility, diseases and death of the mankind. The evolution and development of rasa shastra occurred due to the necessity for using natural products in the field of medicine. Rasashastra medicine specific and quick effects in very small doses and their palatability and long shelf life these metallic and mineral preparations became highly popular and most effective remedies in Ayurveda therapeutic. For Shalakyatantra disorder’s in Rasashastra number of medicine available for treat the Disease, in sushrut samhita uttartantra chapter-18 different types of Netraroga kriya kalpa, Ajjan types and its karma and dose found. Here try to found easiest and suitable aushadhi and their application for the disorders of Netraroga.

Keywords: Anjjan, Netraroga, Sushruta samhita


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