Archives

2022

Vol 4, No 1 (2022): Systematic Implementation of Quality Management Systems in State-Run Medicine-Control Labs

Authors:- Sayali Patil, Shaurya Shete, Jadhav Kamlesh

Abstract:- The article examines the regulatory framework in the field of regulating laboratory operations for quality control of pharmaceuticals at the global and national levels. Considering the harmonisation of the new version of ISO/IEC 17025 "General requirements for the competence of testing and calibration laboratories" and ISO 9001:2015 "Quality management systems. Requirements," the necessity of widespread implementation of the process approach and risk-oriented thinking in laboratory activities has been established. The general techniques to implementing quality management systems (QMS) in pharmaceutical testing laboratories are presented. A example list of QMS procedures of the laboratory for quality control of medicines has been produced, and such processes are recommended to be divided into three groups: management processes, resource provision processes, and major (analytical testing) processes. It is established that these process groups should be defined in the Quality Manual, with a mandated visual depiction of the QMS process model structure and a description of the process interaction conditions. The application of the PDCA Cycle inside each process has been shown to enhance systematic measurement, activity analysis, and the formulation of effective corrective and preventative measures (CAPA). The establishment of effective QMS in state and private laboratories for quality control of pharmaceuticals will aid in reducing the number and significance of inconsistencies and errors in analytical work, as well as providing adequate guarantees for obtaining reliable results, as well as increasing staff awareness of quality management methods and continuous improvement.

Keywords:- Laboratory, Quality management system, Process approach, standards, ISO 9001, ISO 17025, PDCA Cycle, medicines, quality control.

Vol 4, No 1 (2022): Dengue: A Serious Threat to Public Health around the World

Authors:- Priya Saxsena, Pankhudi Choudhary

Abstract:- In recent years, dengue fever cases have been reported from all around the world. Dengue fever is a viral infection that is transmitted to humans by the bite of infected Aedes mosquitos, particularly Aedes aegypti. The goal of this page is to provide information on many aspects of dengue. By reviewing peer-reviewed papers and acquiring access to internationally recognised scientific databases, a bibliographic search was done to retrieve accessible published content (Scopus, PubMed, SciELO, NISCAIR, Google Scholar and WHO Guidelines available during 1994-2016). Overall, 100 papers were thoroughly reviewed, but only 22 research from 1994 to 2016 were chosen for the study. Dengue criteria, transmission, laboratory diagnosis methods, clinical treatment (including a step-by-step approach to dengue management), and vector management are all covered on this page (including biological control). The study's main findings include the recently introduced Caripill tablets and the Dengvaxia immunisation. Caripill tablet has been shown to increase platelet count, which is a big accomplishment. This article will provide a roadmap for clinicians and other healthcare professionals. It will aid in raising public knowledge about dengue. More research on dengue fever is needed.

Keywords:- Dengue; Caripil; Aedes aegypti; Dengvaxia; Platelet count;

Vol 4, No 1 (2022): A Review on Hyperuricemia and the Worldwide Risk of Cardiovascular Disease Current Research and Future Preventive Strate

Authors:- Arjun Dahal, G. Sivakumar, S. Ramesh Babu

Abstract:- Over the last several years, scientific study has focused on the possible significance of hyperuricemia as a cardiovascular risk factor; the major focus has been on persistently elevated plasma uric acid levels. Although some studies have not found a strong link between hyperuricemia and cardiovascular risk, the majority of scientific evidence agrees that hyperuricemia is important in determining cardiovascular events and the development of other risk factors, which are frequently associated with only moderately elevated serum uric acid levels. The pathophysiological mechanisms behind this connection include mostly hyperuricemia-induced endothelial dysfunction, as well as inflammatory and oxidative stress caused by high blood uric acid levels. Early detection, follow-up, and preventative measures, as well as successful hyperuricemia therapy, are especially suggested in patients with additional concurrent cardiovascular risk factors. Urate-lowering medication should aim to achieve a serum uric acid level of less than 6 mg/dL (360 mol/L), while in high-risk individuals, the lowest feasible value of uric acid is preferable.

Keywords:- Cardiovascular Disease, Worldwide Risk, pathophysiological Mechanisms, Hyperuricemia Therapy

Vol 4, No 1 (2022): A Review of Information and Prevention of Communicable Diseases

Authors:- Dr. Chetan Salekar, Arjun Yadav, Ganesh Ahire

Abstract:- In recent decades, natural disasters have killed millions of people, disrupted the lives of nearly one billion people, and resulted in enormous economic compensations. The primary causes of communicable illness in disasters may be categorised into four categories: Among the most prevalent are infections caused by contaminated food and water, respiratory infections, vector and insect-borne illnesses, and infections caused by wounds and trauma. The most prevalent causes of morbidity and death in this situation are diarrheal disease and acute respiratory infections. The purpose of this protocol is to assist the discovery, evaluation, and synthesis of the best available information on the prevention and assessment of the following priority infectious diseases: diarrhoea, hepatitis A and E, leptospirosis, vector-borne illnesses, and wound and injury infections.

Keywords:- Communicable Diseases, Vector-Borne Illnesses, Infectious Disease, Economic Compensations

Vol 4, No 1 (2022): A Comprehensive Analysis of the Current State of Generic Pharmaceuticals in India

Authors:- Bidisha Chaudhuri, Amit Chattopadhyay

Abstract:- Drugs or medications are substances that are used to treat, diagnose, mitigate, or prevent disease. However, it is too costly. Not at all, yet therapy is extremely difficult for poorer and middle-class people due to the high expense of medications. Many people die because they cannot pay the cost of their medications. The introduction of generic drugs into the market resulted in a dramatic shift in the healthcare system, with the market share steadily expanding. The poor and vulnerable elements of society gain since these are genuine, dependable, secure, inexpensive, and available to everybody. There is now an alternative to expensive branded medications. The government of India is taking several initiatives to increase the availability of generic drugs in both rural and urban regions, as well as to educate people about how safe and effective they are in comparison to branded medicines. Many pharmaceutical businesses manufacture generic drugs and distribute them through retail shops. E-pharmacies are also in operation, delivering generic medications to customers' homes. Thousands of Pradhan Mantri Bhartiya Janaushadhi Kendra (PMBJK) have been established around the country to provide generic medications at a considerably lesser cost. The current paper is based on a research to determine the availability of generic medications through PMBJK, a price comparison of generic and branded medicines, the reasons for the lower price of generic medicines, and locations other than PMBJK where generic medicines are accessible.

Keywords:- Pradhan Mantri Bhartiya Janaushadhi Kendra PMBJK, Market share of generic medicines in India, Price comparison of generic and branded medicines.


2021

Vol 3, No 2 (2021): The Use of Natural Remedies for the Treatment of Leukaemia

Authors: Dr. Sharad Tiwari, Devanshu Sharma

Abstract: A case of leukaemia, which was effectively treated using homoeopathic drugs, is described. The treatment regimen includes medications that were prescribed based on the patient's mental symptoms, disease-specific symptoms, and therapy methods. Bone marrow aspiration and trephine biopsy were used to make the diagnosis, which was followed by a regular complete blood count test. The patient has fully recovered from leukaemia and is in good health at this time. Clinical trials involving this homoeopathic therapy procedure are required in order to investigate the therapeutic potential of these drugs in the treatment of leukaemia, according to the authors.

Keywords:Childhood cancer; White blood cells; Juvenile myelomonocytic leukemia

Vol 3, No 2 (2021): Current Therapeutic Options for Parkinson's disease and the Role of Proinflammatory Cytokines

Authors: Priyam Jain, Yogesh Kirar, Sameer Thakur

Abstract: In Parkinson's disease, dopaminergic neurons in the substantia nigra region of the brain gradually degenerate, resulting in a progressive loss of function. Because the origin of this disease is unclear, treatment is symptomatic and ineffective in terms of slowing the progression of the condition. Recent research, on the other hand, has established a clear link between neuroinflammation and proinflammatory cytokines and the pathophysiology of several diseases. A discussion of the relationship between proinflammatory cytokines and the pathophysiology of Parkinson's disease is presented in this paper, which also considers current therapy options that target these pathways.

Keywords: Parkinson's disease; Neurodegenerative disease; Neuroinflammation; Current approaches; Proinflammatory cytokines

Vol 3, No 2 (2021): Treating Diseases like Inflammation and Arthritis with Different Biological Extracts to Help the Body

Authors: Rohit singh Dhanwai, Hemant Kumar

Abstract: Inflammation and the arthritis are the two most irremovable diseases which affect human life at the time of old age. Different preventive measures from all parts of the world are taken into consideration, so that effective and constructible care and a balanced medicine could be made against the concerned bodily arrays. As per the allopathic medicines are taken into consideration they furnish some relief, but only up-to the use of the medicines. But nowadays scientists showed their interest towards the utilisation of medicinal plants against almost all types of diseases. Similarly the present study was carried out about the three medicinal plants viz, Artemisia maritima, Capsicum annuum, Juglans regia against inflammation and arthritis. Among the three plants Juglans regia oil was found most effective against inflammation and arthritis followed by capsicum annum. Also among various extracts  of the concerned plants more polar solvents extracts proved to be more effective as compared to less polar solvent extracts.

Keywords:Arthritis, Capsicum Annuum, Juglans Regia, Artemisia Maritima, Inflammation

Vol 3, No 2 (2021): Molecular Iodine: A Novel Broad-Spectrum Antiviral Agent against SARS-Cov-2

Authors: Srikanta Akumalla, Hamsini Hari kumar, Maithri D. B, Aditi S. Jois

Abstract: Corona viruses are a group of RNA viruses that cause respiratory infection in mammals and birds. The ongoing COVID-19 pandemic has heightened the battle between humans and viruses. At this time, it is critical for everyone to take precautionary measures in order to avoid becoming infected. Physical barriers, such as masks, PPE kits, and face-shields, as well as maintaining social distance, are recommended. Chemical barriers, such as hand sanitizers, sprays, and hand-washes, are also recommended along with vaccinations. Another lesser-known but well-proven method for combating Covid is to use Iodine as an antiviral agent. Iodine has broad-spectrum disinfectant properties. According to laboratory studies, iodine exposure inactivates the SARS virus within few minutes. Iodine can be taken in the form of Povidone-iodine (PVP-I) gargles or Iodine V (available in the form of Essential Iodine Drops) or the use of molecular iodine (I2) in the form of lotion (I2 Cure). Iodine acts on viruses by damaging viral surface proteins and lipid coating. Free iodine can cause irreversible damage to the virus by degrading viral nucleoproteins, oxidising nucleic acids, and disrupting metabolic pathways. Furthermore, free iodine is an anti-inflammatory agent during viral infections because it scavenges free radicals. Iodine's above action results in the inactivation of the cell/viral particle. Although the use of iodine seems as a promising method of inactivating viruses, the effects of long-term exposure to Iodine is not fully evaluated.

The purpose of this paper is to understand a relatively unknown but well-proven mode of disinfection, namely the use of molecular iodine, against Corona virus.

Keywords: COVID, Molecular Iodine, Antiviral agent, Antimicrobial Agent, SARS-CoV-2

Vol 3, No 2 (2021): A Systematic Review on Oral Lichen Planus: Pathogenesis and its Treatment

Authors: Krishna Dhungana, Sunil Gupta, Daisy Arora

Abstract: Oral lichen planus (LIE-kun PLAY-nus) is an ongoing (chronic) inflammatory condition that affects mucous membranes inside your mouth. Oral lichen planus may appear as white, lacy patches; red, swollen tissues; or open sores. These lesions may cause burning, pain or other discomfort. Oral lichen planus can't be passed from one person to another. The disorder occurs when the immune system mounts an attack against cells of the oral mucous membranes for unknown reasons. Symptoms can usually be managed, but people who have oral lichen planus need regular monitoring because they may be at risk of developing mouth cancer in the affected areas. The white, lacy patches may not cause discomfort when they appear on the inside of the cheeks. However, symptoms accompanying red, swollen patches and open sores may include burning sensation or pain. Some factors may increase your risk of developing oral lichen planus, such as having a disorder that lowers your immunity or taking certain medications, though more research is needed. In the present review a brief pathophysiology and different treatment approaches are discussed in brief.

Keywords: Oral Lichen planus, immunity, open sores, corticosteroids, nutraceuticles.

Vol 3, No 1 (2021): Sports Medicine as a New Frontier for Ayurveda

Authors: Kavita Gupta, Mahima Sharma

Abstract: Ayurveda, an ancient Indian medical system, is one of the most important systems of alternative medicine. Due to its distinct unmatched concept, it is proven to be highly practical even in the current period of medicine. We can't find any field of current medicine that has explanations of sports medicine from two centuries ago, and the same is true of Ayurvedic literature. However, in this modern era of medicine, the discipline of medicine is becoming increasingly multidisciplinary by combining information from other professions. In contemporary medicine, the area of sports medicine has just recently evolved as a separate department. As a result, Ayurvedic practitioners began to use the term "sports medicine" and chose a number of traditional, time-tested formulas that were discovered to be acceptable for prescription for modern-day sports injuries. They also took many of the formulas and procedures used in many ancient martial arts schools and produced numerous contemporary medicaments based on them. This study tries to describe this new subject by mentioning historic formulations as well as current pharmaceuticals.

Vol 3, No 1 (2021): Formulations of Poly Herbal Gel based Hand Sanitizer

Authors: Sidat Parin S., Ashara S.Jeesha.,Varachia AyshaI., Vanshiya Shivangini K., Unagar Ajay H., Virani G.Smit.

Abstract: The primary mode of transmission of microbes and infections is through the hands. Hand hygiene is thus the most important measure for avoiding the transmission of harmful germs and preventing infections. Hand sanitizer kills hazardous microorganisms on the hands while also preventing scratching, irritation, and dermatitis. The main aim of this research work is to develop a polyherbal hand sanitizer that is both alcohol-based and alcohol-free. Various essential oils, water and IPA, extracts of Neem leaf (Azadiractaindica), Tulsi leaf Ocimum sanctum L.), Kesudo leaf, Orange peel, Pulp of Aloe, were components of the hand sanitizers instead of synthetic ingredients. All of the ingredients have antimicrobial properties and smoothing effects on the hands. Physicochemical parameters such as pH, viscosity, and foam stability were determined along with antibacterial activity of hand sanitizer on selected strains of microorganisms. The findings show that the formulations have strong appearance characteristics, and the sanitizer's overall characterization showed that the formulations have no unpleasant color or odor.

Keywords: Hand sanitizer, Hand hygiene, Essential oils, Plant extracts

Vol 3, No 1 (2021): Determinants Influencing the Relapse of SARS-Cov-2 Infections in COVID-19 Pandemic

Author: Arathi Radhakrishanan, Chanchal Srivastav, Chandresh Sharma, Chanderdeep Tandon, Rajpal Srivatsav

Abstract: The pandemic COVID-19 caused by SARS-CoV-2, has been responsible for millions of deaths, highest in world history in a year. Most countries have been affected by COVID-19 and this viral infection has become a serious threat to public health worldwide. There are many reports indicating the relapse of COVID-19. Millions of people have been infected and recovered from SARS-CoV-2 infection. However, there are ambiguities regarding the immunity elicited by SARS-CoV-2. Numerous cases have been reported worldwide about the relapse and reoccurrence of the disease. This has led to the discussion regarding the immune response and immunity developed after infection. There are multiple factors responsible for the relapse of COVID-19. The relevance of relapse phenomenon cannot be underscored and the factors responsible should be monitored for successfully combating the disease. Hence, the focus should be to understand the relapse phenomenon and various factors responsible for this condition. SARS-CoV-2 is undergoing continuous mutational changes to adapt for higher pathogenicity and rapid transmission. Therefore, there is requisite to understand the relapse mechanism and the factors responsible of COVID-19.

Keywords: COVID-19, Coronavirus, SARS-CoV-2, Immune response, Vaccine, Relapse infection.

 

Vol 3, No 1 (2021): Rosacea: Pathophysiology, Differential Diagnosis and Treatment Modalities

Authors: Varsha Sodhi, Raj Kumar Narang, Daisy Arora

Abstract: Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we presented the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We have also described the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid in better comprehending its complex pathogenesis.

Keywords: Rosacea; Inflammation; cutaneous disorder; Facial erythema; papules


2020

Vol 2, No 2 (2020): A Review on Medication and Management of Liver Cirrhosis

Authors:-Yuvrajsinh Solanki, Preetu Shukla, Dr. U. M. Upadhyay

Abstract:-Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, which leads to portal hypertension and end stage liver diseases. Recent advances in the understanding of the natural history and pathophysiology of cirrhosis, and in treatment of its complications, have resulted in improved management, quality of life and life expectancy of patients. Liver transplantation remains the only curative options for selected group of patients, but pharmacological treatments that can halt progression to decomposed cirrhosis or even reverse cirrhosis are currently being developed. This review focuses on the history, causes, sign & symptoms, diagnosis, complications, and management of cirrhosis and new clinical and scientific developments.

Vol 2, No 2 (2020): Multi Particulate Drug Delivery System

Authors: Bhatt Kruti Nileshbhai1, Dr. Jitendra Patel2, Dr. U.M. Upadhyay

Abstract: Multiparticulate drug delivery system is increasing desire effect over single unit dosages forms because of their potential benefits. Multiparticulate systems provide predictable gastric emptying, no risk of dose dumping, flexible release pattern and increased bioavailability with less inter and Intra subject variability. The aim of this review is to provide the main multiparticulate pulsatile delivery system, for which the swelling and rupturing and changed permeability of the coating membrane is primarily involved in the control of release. Ulcerative colitis is the chronic relapsing multifactorial gastrointestinal inflammatory bowel disease, which is characterized by bloody diarrhea, bowel dysfunction, anaemia.  The main aim is to overcome ulcerative colitis is appropriate local targeting and drug-related side-effects. To overcome these problems, microparticulate systems seems to be a promising approach for controlled and sustained drug release after oral administration, with this drug delivery system increasing immense importance for the local targeting drug to the colon at a controlled and sustained rate.

 

Prior to the development of any system, due consideration must be given to the physiological changes that occur in the disease state that might affect the performance of such a system. In spite of such physiological constraints to drug delivery to the colon, several colon-targeted formulations have been successfully commercialized in US and European markets. Few of the commercialized products are listed in Table 1. Several reviews have been published reporting the research that has gone into the development of perorally delivered single unit colon targeted drug delivery systems (24-30). In general, four primary approaches have been proposed for colon targeted delivery, namely prodrugs, pH-dependent system, time-dependent systems and colonic microflora activated systems (27). A brief summary of some of the colon targeted formulations based on the above mentioned conventional approaches is given in Table 2. Single unit colon targeted drug delivery system may suffer from the disadvantage of unintentional disintegration of the formulation due to manufacturing deficiency or unusual gastric physiology that may lead to drastically compromised systemic drug bioavailability or loss of local therapeutic action in the colon. Recently, much emphasis is being laid on the development of multiparticulate dosage forms in comparison to single-unit systems because of their potential benefits like increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying (31). Multiparticulate approaches tried for colonic delivery include includes formulations in the form of pellets, granules, microparticles and nanoparticles. The use of multiparticulate drug delivery systems in preference to single unit dosage forms for colon targeting purposes dates back to 1985 when Hardy and co-workers (32) showed that multiparticulate systems enabled the drug to reach the colon quickly and were retained in the ascending colon for a relatively long period of time. Because of their smaller particle size as compared to single unit dosage forms, these systems are capable of passing through the GI tract easily, leading to less inter-and intra-subject variability. Moreover, multiparticulate systems tend to be more uniformly dispersed in the GI tract and also ensure more uniform drug absorption (33-35).

Vol 2, No 2 (2020): A Comprehensive Literature Review of Coronavirus Pandemic: Therapeutic Options and Possible Lessons from SARS-CoV

Authors: P. S. Meher, Dr. J.R. Rao

Abstract: There are new public health emergencies debilitating the world with the spread of the coronavirus disease in 2019. This presents an inventive challenge to identify useful drugs for therapy. A new coronavirus was found in China, Wuhan city, in December 2019. A causative agent earlier termed COVID-19 by WHO. It affects the lower respiratory tract and explicit as pneumonia in humans. The disease is transferred by inhalation or in contact with infected surfaces. The evaluation and exposure to the pathogenic organism period of the virus is between 2 to 14 days. The common symptoms observed usually are cough, fever, fatigue and sore throat, among others. The number of people is asymptomatic. The present review includes in detail information of virus, its epidemiology, symptoms, diagnostic tests, prevention, some useful therapies and drugs which may be effective in treatment.

Vol 2, No 1 (2020): Challenges and Opportunities for Covid-19 Management: An Outbreak

Authors:-Ramandeep Saini, N.S. Gill1, Yash Prashar Manoj Kumar Katual, Gurfateh Singh,S. L. Harikumar

 

Abstract:-Corona virus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome corona virus 2(SARS-CoV-2). The disease was first identified in 2019 in Wuhan, the capital of Hubei, China, and has since spread globally, resulting in the 2019–20 corona virus pandemic. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include muscle pain, sputum production, diarrhoea, sore throat, and loss of smell and taste. While the majority of cases result in mild symptoms, some progress to pneumonia and multi-organ failure. As of 25 March 2020, the overall rate of deaths per number of diagnosed cases is 4.5 percent, but it in fact ranges from 0.2 percent to 15 percent according to age group and other health problems. The virus is typically spread during close contact and via respiratory droplets produced when people cough or sneeze. Respiratory droplets may be produced during breathing but it is not considered airborne. It may also spread when one touches a contaminated surface and then their face. It is most contagious when people are symptomatic, although spread may be possible before symptoms appear. The virus can live on surfaces up to 72 hours. Time from exposure to onset of symptoms is generally between two and fourteen days, with an average of five days. The standard method of diagnosis is by reverse transcription polymerase chain reaction (rRT-PCR) from a nasopharyngeal swab. The infection can also be diagnosed from a combination of symptoms, risk factors and a chest CT scan showing features of pneumonia. Recommended measures to prevent infection include frequent hand washing, social distancing (maintaining physical distance from others, especially from those with symptoms), covering coughs and sneezes with a tissue or inner elbow, and keeping unwashed hands away from the face. The use of masks is recommended by some national health authorities for those who suspect they have the virus and their caregivers, but not for the general public, although simple cloth masks may be used by those who desire them. There is no vaccine or specific antiviral treatment forCOVID-19. Management involves treatment of symptoms, supportive care, isolation, and experimental measures. The World Health Organization (WHO) declared the 2019–20 corona virus outbreak a Public Health Emergency of International Concern (PHEIC) on 30 January 2020and a pandemic on 11 March 2020. Local transmission of the disease has been recorded in many countries across all six WHO regions.


2019

Vol 1, No 2 (2019): Dust and Allergy

Authors: Dr. S. Sreeremya

Abstract: Dust is a polluting agent which causes major pulmonary disorders which initially starts from coughing to chronic clinical conditions.  It can cause eye infections too. This paper discusses the mode of infections manifested by dust as allergen.

 

Vol 1, No 2 (2019): Influence of Acinetobacter in Coming Era

Authors: Dr. S. Sreeremya

Abstract: Acinetobacter baumannii is the Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has the high incidence among immunocompromised individuals, particularly those who have experienced the prolonged (> 90 d) hospital stay. Commonly allied with aquatic environments, it has been shown to colonize the skin as well as being isolated in very high numbers from the respiratory and oropharynx secretions of infected individuals. So this paper discusses the various aspects of Acinetobacter baumannii

Vol 1, No 1 (2019): Contagious Disease in Camels: Jhooling

Authors:-Sreeremya .S

Abstract:-There are so many contagious diseases affecting in camels. There are several contagious infections like pox, staphylococcal infection, enteric infections etc. Jhooling is one among them. In this paper the pathogen city and disease which mostly affects the camels are discussed.

Vol 1, No 1 (2019): KISSING DISEASE (Infectious Mononucleosis)

Author: Sreeremya. S

Abstract: Infectious mononucleosis, or "mono" for short, is a viral illness that is common in teens and young adults. Although several viruses can cause mono, 92% of cases are caused by the Epstein-Barr virus (EBV). By middle adulthood, 95% of Americans have antibodies against EBV and thus have been infected at some point. This paper provides information regarding the clinical manifestation of Infectious mononucleosis (Kissing disease).

Vol 1, No 1 (2019): Molecular Aspects of Hammer Head Ribozyme Isolated From Virus& Its Influence on RNA Biology

Author: Sreeremya. S

Abstract: The field of RNA biology is now advancing sporadically. Hammer head ribozyme motif has a great role to play in RNA biology. This was first isolated from viruses. They are used o cleave other RNA molecules; can be vastly used in genetic manipulations. This paper garners the information regarding the functions, unique properties of Hammer head ribozymes.

Vol 1, No 1 (2019): Cauda Equina Syndrome Bowel Dysfunction

Authors:-S. Sreeremya

Abstract:-Cauda equina syndrome (CES) is a chronic Complication of lumbar spinal disorders; it results from compression of the nerve roots of the cauda equina. The purpose of this work  was to assess the clinical usefulness of a classification scheme of CES based on certain factors including clinical symptoms, imaging signs, and electrophysiological findings.


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